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RNA tissue category: Group enriched (appendix, small intestine, colon)
GENE INFORMATION
Gene name
NOS2 (HGNC Symbol)
Synonyms
HEP-NOS, iNOS, NOS, NOS2A
Description
Nitric oxide synthase 2, inducible (HGNC Symbol)
Entrez gene summary
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001912 [positive regulation of leukocyte mediated cytotoxicity] GO:0002227 [innate immune response in mucosa] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004517 [nitric-oxide synthase activity] GO:0005102 [receptor binding] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0006527 [arginine catabolic process] GO:0006801 [superoxide metabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0006954 [inflammatory response] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0007623 [circadian rhythm] GO:0009617 [response to bacterium] GO:0010181 [FMN binding] GO:0010629 [negative regulation of gene expression] GO:0016491 [oxidoreductase activity] GO:0018119 [peptidyl-cysteine S-nitrosylation] GO:0020037 [heme binding] GO:0030863 [cortical cytoskeleton] GO:0031284 [positive regulation of guanylate cyclase activity] GO:0032496 [response to lipopolysaccharide] GO:0034617 [tetrahydrobiopterin binding] GO:0034618 [arginine binding] GO:0035690 [cellular response to drug] GO:0042127 [regulation of cell proliferation] GO:0042177 [negative regulation of protein catabolic process] GO:0042742 [defense response to bacterium] GO:0042803 [protein homodimerization activity] GO:0043457 [regulation of cellular respiration] GO:0045776 [negative regulation of blood pressure] GO:0045909 [positive regulation of vasodilation] GO:0048471 [perinuclear region of cytoplasm] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0050796 [regulation of insulin secretion] GO:0050829 [defense response to Gram-negative bacterium] GO:0051712 [positive regulation of killing of cells of other organism] GO:0055114 [oxidation-reduction process] GO:0071222 [cellular response to lipopolysaccharide] GO:0071346 [cellular response to interferon-gamma] GO:0090382 [phagosome maturation]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001912 [positive regulation of leukocyte mediated cytotoxicity] GO:0002227 [innate immune response in mucosa] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004517 [nitric-oxide synthase activity] GO:0005102 [receptor binding] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0006527 [arginine catabolic process] GO:0006801 [superoxide metabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0006954 [inflammatory response] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0009617 [response to bacterium] GO:0010181 [FMN binding] GO:0010629 [negative regulation of gene expression] GO:0016491 [oxidoreductase activity] GO:0018119 [peptidyl-cysteine S-nitrosylation] GO:0020037 [heme binding] GO:0031284 [positive regulation of guanylate cyclase activity] GO:0034617 [tetrahydrobiopterin binding] GO:0034618 [arginine binding] GO:0042742 [defense response to bacterium] GO:0042803 [protein homodimerization activity] GO:0043457 [regulation of cellular respiration] GO:0045776 [negative regulation of blood pressure] GO:0045909 [positive regulation of vasodilation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0050796 [regulation of insulin secretion] GO:0050829 [defense response to Gram-negative bacterium] GO:0051712 [positive regulation of killing of cells of other organism] GO:0055114 [oxidation-reduction process] GO:0090382 [phagosome maturation]