Cell atlas - GAS7 - The Human Protein Atlas

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GAS7

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Focal adhesion sites
	Plasma membrane

Human cell
	Actin Filaments
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GAS7
Gene description	Growth arrest-specific 7
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, actin filaments & focal adhesion sites.
RNA cell category	Cell line enriched (WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Actin filaments (approved), Focal adhesion sites (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064678
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, actin filaments & focal adhesion sites.

Main location

Plasma membrane (approved), Actin filaments (approved), Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064678	SK-MEL-30	Plasma membrane	Intensity
	HPA064678	SK-MEL-30	Actin filaments	Intensity
	HPA064678	U-2 OS	Plasma membrane
	HPA064678	U-2 OS	Focal adhesion sites

GENE INFORMATION
Gene name	GAS7 (HGNC Symbol)
Synonyms	KIAA0394, MGC1348
Description	Growth arrest-specific 7 (HGNC Symbol)
Entrez gene summary	Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	9910609 - 10198551
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000007237 (version 83.38)
Entrez gene	8522
UniProt	O60861 (UniProt - Evidence at protein level)
neXtProt	NX_O60861
Antibodypedia	GAS7 antibodies

PROTEIN BROWSER

GAS7-001	GAS7-002	GAS7-003	GAS7-005	GAS7-009	GAS7-010	GAS7-013	GAS7-016	GAS7-017	GAS7-018	GAS7-019	GAS7-022	GAS7-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAS7-001 ENSP00000464240 ENST00000585266	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	416 aa 47.7 kDa	No	0
GAS7-002 ENSP00000322608 ENST00000323816	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	416 aa 47.7 kDa	No	0
GAS7-003 ENSP00000410108 ENST00000437099	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	412 aa 47.3 kDa	No	0
GAS7-005 ENSP00000464088 ENST00000583882	J3QR80 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.9 kDa	No	0
GAS7-009 ENSP00000462304 ENST00000584146	J3KS47 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	179 aa 19.8 kDa	No	0
GAS7-010 ENSP00000443265 ENST00000542249	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	412 aa 47.3 kDa	No	0
GAS7-013 ENSP00000463551 ENST00000580043	J3QLH8 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	106 aa 11.3 kDa	No	0
GAS7-016 ENSP00000463873 ENST00000580865	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	336 aa 39.2 kDa	No	0
GAS7-017 ENSP00000407552 ENST00000432992	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005884 [actin filament] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008360 [regulation of cell shape] GO:0030041 [actin filament polymerization] GO:0030182 [neuron differentiation] GO:0048812 [neuron projection morphogenesis] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] Show all	476 aa 54.4 kDa	No	0
GAS7-018 ENSP00000462897 ENST00000584389	J3KTB1 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	128 aa 13.8 kDa	No	0
GAS7-019 ENSP00000464494 ENST00000578599	J3QS26 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	141 aa 15.5 kDa	No	0
GAS7-022 ENSP00000463527 ENST00000579158	O60861 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] Show all	412 aa 47.3 kDa	No	0
GAS7-024 ENSP00000379421 ENST00000396115	A0A0A0MS68 [Direct mapping] Growth arrest-specific protein 7 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	181 aa 20.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.