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A majority of malignant cells were weakly or moderately stained in the cytoplasm. Most cases of cervical, lung, skin, malignant glioma and lymphoma were negative.
GENE INFORMATION
Gene name
BAIAP3 (HGNC Symbol)
Synonyms
BAP3, KIAA0734
Description
BAI1-associated protein 3 (HGNC Symbol)
Entrez gene summary
This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]