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NOX1

GENERAL INFORMATION

Gene name

 NOX1

Gene description

 NADPH oxidase 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (rectum, colon)
GTEx:Tissue enriched (colon)
FANTOM5:Group enriched (colon, seminal vesicle, appendix)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (rectum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, seminal vesicle, appendix)

GENE INFORMATION

Gene name

 NOX1 (HGNC Symbol)

Synonyms

 GP91-2, MOX1, NOH-1, NOH1

Description

 NADPH oxidase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 100843324 - 100874345

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007952 (version 83.38)

Entrez gene

 27035

UniProt

 Q9Y5S8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5S8

Antibodypedia

 NOX1 antibodies

PROTEIN BROWSER
NOX1-001
NOX1-002
NOX1-003
NOX1-004
NOX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOX1-001
ENSP00000362057
ENST00000372966
Q9Y5S8 [Direct mapping]
NADPH oxidase 1
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006739 [NADP metabolic process]
GO:0006801 [superoxide metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016477 [cell migration]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0030171 [voltage-gated proton channel activity]
GO:0030198 [extracellular matrix organization]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042554 [superoxide anion generation]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0043020 [NADPH oxidase complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045730 [respiratory burst]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0048365 [Rac GTPase binding]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050661 [NADP binding]
GO:0051454 [intracellular pH elevation]
GO:0055114 [oxidation-reduction process]
GO:0071438 [invadopodium membrane]
GO:0071455 [cellular response to hyperoxia]
GO:0072592 [oxygen metabolic process]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990451 [cellular stress response to acidic pH]
Show all
 564 aa
64.9 kDa 		No 7
NOX1-002
ENSP00000362055
ENST00000372964
Q5H9D4 [Direct mapping]
NADPH oxidase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 192 aa
22 kDa 		No 4
NOX1-003
ENSP00000217885
ENST00000217885
Q9Y5S8 [Direct mapping]
NADPH oxidase 1
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006739 [NADP metabolic process]
GO:0006801 [superoxide metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016477 [cell migration]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0030171 [voltage-gated proton channel activity]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042554 [superoxide anion generation]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0043020 [NADPH oxidase complex]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045730 [respiratory burst]
GO:0046872 [metal ion binding]
GO:0048365 [Rac GTPase binding]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050661 [NADP binding]
GO:0051454 [intracellular pH elevation]
GO:0055114 [oxidation-reduction process]
GO:0071438 [invadopodium membrane]
GO:1990451 [cellular stress response to acidic pH]
Show all
 515 aa
59 kDa 		No 7
NOX1-004
ENSP00000396992
ENST00000427768
H0Y581 [Direct mapping]
NADPH oxidase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 175 aa
20.3 kDa 		No 0
NOX1-201
ENSP00000362051
ENST00000372960
A6NGA6 [Direct mapping]
NADPH oxidase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 527 aa
60.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.