Cell atlas - CDK11A - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CDK11A

premium

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CDK11A
Gene description	Cyclin-dependent kinase 11A
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB010467 , HPA073626
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

Nuclear speckles (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010467	A-431	Nuclear speckles
	CAB010467	A-431	Cytosol
	CAB010467	U-2 OS	Nuclear speckles
	CAB010467	U-2 OS	Cytosol
	HPA073626	SK-MEL-30	Nuclear speckles
	HPA073626	SiHa	Nuclear speckles
	HPA073626	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	CDK11A (HGNC Symbol)
Synonyms	CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE
Description	Cyclin-dependent kinase 11A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1702730 - 1724324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008128 (version 83.38)
Entrez gene	728642
UniProt	Q9UQ88 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQ88
Antibodypedia	CDK11A antibodies

PROTEIN BROWSER

CDK11A-001	CDK11A-003	CDK11A-004	CDK11A-005	CDK11A-007	CDK11A-008	CDK11A-011	CDK11A-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK11A-001 ENSP00000384442 ENST00000404249	Q9UQ88 [Direct mapping] Cyclin-dependent kinase 11A Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0050684 [regulation of mRNA processing] GO:0051726 [regulation of cell cycle] Show all	780 aa 91 kDa	No	0
CDK11A-003 ENSP00000350403 ENST00000357760	Q5QPR3 [Direct mapping] Cyclin-dependent kinase 11A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	779 aa 91 kDa	No	0
CDK11A-004 ENSP00000351629 ENST00000358779	Q9UQ88 [Direct mapping] Cyclin-dependent kinase 11A Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0050684 [regulation of mRNA processing] GO:0051726 [regulation of cell cycle] Show all	770 aa 90 kDa	No	0
CDK11A-005 ENSP00000367900 ENST00000378633	Q9UQ88 [Direct mapping] Cyclin-dependent kinase 11A Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0050684 [regulation of mRNA processing] GO:0051726 [regulation of cell cycle] Show all	783 aa 91.4 kDa	No	0
CDK11A-007 ENSP00000423900 ENST00000479362	E9PFJ2 [Direct mapping] Cyclin-dependent kinase 11A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	151 aa 18.9 kDa	No	0
CDK11A-008 ENSP00000348529 ENST00000356200	Q5QPR4 [Direct mapping] Cyclin-dependent kinase 11A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	746 aa 86.8 kDa	No	0
CDK11A-011 ENSP00000383874 ENST00000401096	Q5QPQ9 [Direct mapping] Cyclin-dependent kinase 11A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.6 kDa	No	0
CDK11A-027 ENSP00000367905 ENST00000378638	Q5QPR4 [Direct mapping] Cyclin-dependent kinase 11A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	746 aa 86.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.