Tissue expression of ADAM22 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADAM22
Gene description	ADAM metallopeptidase domain 22
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	ADAM22 (HGNC Symbol)
Synonyms	MDC2
Description	ADAM metallopeptidase domain 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Chromosome	7
Cytoband	q21.12
Chromosome location (bp)	87934143 - 88202889
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008277 (version 83.38)
Entrez gene	53616
UniProt	Q9P0K1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0K1
Antibodypedia	ADAM22 antibodies

PROTEIN BROWSER

ADAM22-001	ADAM22-002	ADAM22-003	ADAM22-004	ADAM22-005	ADAM22-006	ADAM22-007	ADAM22-008	ADAM22-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM22-001 ENSP00000265727 ENST00000265727	Q9P0K1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007162 [negative regulation of cell adhesion] GO:0007417 [central nervous system development] GO:0008270 [zinc ion binding] GO:0008344 [adult locomotory behavior] GO:0014037 [Schwann cell differentiation] GO:0016021 [integral component of membrane] GO:0022011 [myelination in peripheral nervous system] GO:0030424 [axon] GO:0042063 [gliogenesis] Show all	906 aa 100.4 kDa	Yes	1
ADAM22-002 ENSP00000381267 ENST00000398209	Q9P0K1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007162 [negative regulation of cell adhesion] GO:0007417 [central nervous system development] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0030424 [axon] Show all	899 aa 100.3 kDa	Yes	1
ADAM22-003 ENSP00000381262 ENST00000398204	Q9P0K1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007162 [negative regulation of cell adhesion] GO:0007417 [central nervous system development] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0030424 [axon] Show all	870 aa 96.6 kDa	Yes	1
ADAM22-004 ENSP00000381260 ENST00000398201	Q9P0K1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007162 [negative regulation of cell adhesion] GO:0007417 [central nervous system development] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0030424 [axon] Show all	859 aa 95.3 kDa	Yes	1
ADAM22-005 ENSP00000396233 ENST00000426930	H7C0Q9 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	330 aa 36.1 kDa	No	1
ADAM22-006 ENSP00000412085 ENST00000413139	H7C3I4 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	264 aa 29.4 kDa	No	1
ADAM22-007 ENSP00000391334 ENST00000439864	E7EPF1 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	342 aa 39.6 kDa	Yes	0
ADAM22-008 ENSP00000381261 ENST00000398203	F8WAD8 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	804 aa 89.5 kDa	No	1
ADAM22-009 ENSP00000413899 ENST00000412441	E9PF78 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 22 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	196 aa 21.9 kDa	Yes	0