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PAX7

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GENERAL INFORMATION

Gene name

 PAX7

Gene description

 Paired box 7

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (U-2 OS, CAPAN-2, A549)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-2 OS, CAPAN-2, A549)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PAX7 (HGNC Symbol)

Synonyms

 Hup1

Description

 Paired box 7 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 18631006 - 18748866

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000009709 (version 83.38)

Entrez gene

 5081

UniProt

 P23759 (UniProt - Evidence at protein level)

neXtProt

 NX_P23759

Antibodypedia

 PAX7 antibodies

PROTEIN BROWSER
PAX7-001
PAX7-002
PAX7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAX7-001
ENSP00000364524
ENST00000375375
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007519 [skeletal muscle tissue development]
GO:0009653 [anatomical structure morphogenesis]
GO:0010453 [regulation of cell fate commitment]
GO:0010468 [regulation of gene expression]
GO:0014813 [skeletal muscle satellite cell commitment]
GO:0021527 [spinal cord association neuron differentiation]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0031062 [positive regulation of histone methylation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043393 [regulation of protein binding]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060415 [muscle tissue morphogenesis]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 520 aa
56.9 kDa 		No 0
PAX7-002
ENSP00000403389
ENST00000420770
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 505 aa
55.1 kDa 		No 0
PAX7-003
ENSP00000383502
ENST00000400661
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 518 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.