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Few cases of endometrial cancers displayed moderate nuclear staining while rare cases of squamous cell carcinomas of lung, melanoma, urothelial and pancreatic cancer showed strong positivity. Rare cases of breast and prostate cancers displayed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
IFFO1 (HGNC Symbol)
Synonyms
HOM-TES-103, IFFO
Description
Intermediate filament family orphan 1 (HGNC Symbol)
Entrez gene summary
This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
