Expression of GIPR in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Gastric inhibitory polypeptide receptor

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB022710

GENE INFORMATION
Gene name	GIPR
Synonyms
Description	Gastric inhibitory polypeptide receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45668244 - 45683724
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010310 (version 83.38)
Entrez gene	2696
UniProt	P48546 (UniProt - Evidence at protein level)
neXtProt	NX_P48546
Antibodypedia	GIPR antibodies

PROTEIN BROWSER

GIPR-001	GIPR-002	GIPR-003	GIPR-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GIPR-001 ENSP00000467494 ENST00000590918	P48546 [Direct mapping] Gastric inhibitory polypeptide receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007584 [response to nutrient] GO:0009749 [response to glucose] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016519 [gastric inhibitory peptide receptor activity] GO:0017046 [peptide hormone binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031018 [endocrine pancreas development] GO:0032024 [positive regulation of insulin secretion] GO:0038192 [gastric inhibitory peptide signaling pathway] GO:0048678 [response to axon injury] GO:0051592 [response to calcium ion] GO:0070542 [response to fatty acid] Show all	466 aa 53.2 kDa	Yes	7
GIPR-002 ENSP00000263281 ENST00000263281	P48546 [Direct mapping] Gastric inhibitory polypeptide receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007584 [response to nutrient] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0038192 [gastric inhibitory peptide signaling pathway] Show all	419 aa 48.1 kDa	Yes	7
GIPR-003 ENSP00000305321 ENST00000304207	P48546 [Direct mapping] Gastric inhibitory polypeptide receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007584 [response to nutrient] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0038192 [gastric inhibitory peptide signaling pathway] Show all	430 aa 49.1 kDa	Yes	7
GIPR-005 ENSP00000465385 ENST00000591322	K7EJZ3 [Direct mapping] Gastric inhibitory polypeptide receptor Show all	Predicted intracellular proteins Show all		17 aa 1.9 kDa	No	0