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Malignant cells generally showed weak to moderate cytoplasmic staining. Fractions of squamous cell carcinomas and urothelial cancers were the strongly positive.
GENE INFORMATION
Gene name
STAB1 (HGNC Symbol)
Synonyms
CLEVER-1, FEEL-1, FELE-1, FEX1, KIAA0246, STAB-1
Description
Stabilin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]
