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A majority of malignant cells were weakly stained or negative. Liver malignancies exhibited moderate to strong cytoplasmic immunoreactivity while several cases of prostate, thyroid and endometrial cancers were moderately positive.
Ubiquitous cytoplasmic staining in most malignancies, strongest staining in lymphomas and melanomas and malignant carcinoids. Skin and renal cancers were negative or weakly stained.
GENE INFORMATION
Gene name
RNF216 (HGNC Symbol)
Synonyms
TRIAD3, UBCE7IP1, ZIN
Description
Ring finger protein 216 (HGNC Symbol)
Entrez gene summary
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]