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PTBP1

GENERAL INFORMATION

Gene name

 PTBP1

Gene description

 Polypyrimidine tract binding protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB013507
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PTBP1 (HGNC Symbol)

Synonyms

 HNRNP-I, HNRPI, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4

Description

 Polypyrimidine tract binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 797075 - 812327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011304 (version 83.38)

Entrez gene

 5725

UniProt

 P26599 (UniProt - Evidence at protein level)

neXtProt

 NX_P26599

Antibodypedia

 PTBP1 antibodies

PROTEIN BROWSER
«
PTBP1-001
PTBP1-002
PTBP1-003
PTBP1-006
PTBP1-011
PTBP1-012
PTBP1-013
PTBP1-016
PTBP1-017
PTBP1-019
PTBP1-020
PTBP1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTBP1-001
ENSP00000349428
ENST00000356948
P26599 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0008187 [poly-pyrimidine tract binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0033119 [negative regulation of RNA splicing]
GO:0036002 [pre-mRNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0051148 [negative regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
Show all
 557 aa
59.6 kDa 		No 0
PTBP1-002
ENSP00000408096
ENST00000394601
P26599 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0008187 [poly-pyrimidine tract binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0033119 [negative regulation of RNA splicing]
GO:0036002 [pre-mRNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0051148 [negative regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
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 550 aa
59 kDa 		No 0
PTBP1-003
ENSP00000014112
ENST00000349038
P26599 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0008187 [poly-pyrimidine tract binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0033119 [negative regulation of RNA splicing]
GO:0036002 [pre-mRNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0051148 [negative regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
Show all
 531 aa
57.2 kDa 		No 0
PTBP1-006
ENSP00000465652
ENST00000589575
K7EKJ7 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 238 aa
25.4 kDa 		No 0
PTBP1-011
ENSP00000466250
ENST00000585535
K7ELW5 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
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 105 aa
11.2 kDa 		No 0
PTBP1-012
ENSP00000465825
ENST00000587094
K7EKX4 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
5.7 kDa 		No 0
PTBP1-013
ENSP00000468565
ENST00000586481
K7ES59 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 149 aa
15.6 kDa 		No 0
PTBP1-016
ENSP00000465451
ENST00000585956
K7EK45 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 256 aa
27.1 kDa 		No 0
PTBP1-017
ENSP00000478974
ENST00000587191
A0A087WUW5 [Direct mapping]
Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
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 82 aa
9.1 kDa 		No 0
PTBP1-019
ENSP00000342332
ENST00000350092
A6NLN1 [Direct mapping]
Polypyrimidine tract binding protein 1, isoform CRA_b; Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
Show all
 527 aa
56.5 kDa 		No 0
PTBP1-020
ENSP00000489604
ENST00000635647
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
Show all
 588 aa
62.5 kDa 		No 0
PTBP1-201
ENSP00000486218
ENST00000627714
A0A0D9SF20 [Direct mapping]
Polypyrimidine tract binding protein 1, isoform CRA_e; Polypyrimidine tract-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
Show all
 197 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.