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Most of the cancer tissues displayed moderate to strong nuclear positivity with additional cytoplasmic staining in several cases. Most prostate cancers, several endometrial cancers, a few breast and renal cancers were negative.
Cancer tissues showed moderate cytoplasmic staining. Several renal cell carcinomas and hepatocellular carcinomas along with a few cases of ovarian and pancreas cancers displayed strong positivity.
GENE INFORMATION
Gene name
PIK3C2A (HGNC Symbol)
Synonyms
PI3K-C2alpha
Description
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]