Expression of GABRA3 in cancer - Summary

CANCER ATLAS

Gene description

Gamma-aminobutyric acid (GABA) A receptor, alpha 3

Protein class

FDA approved drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000839

GENE INFORMATION
Gene name	GABRA3
Synonyms
Description	Gamma-aminobutyric acid (GABA) A receptor, alpha 3 (HGNC Symbol)
Entrez gene summary	GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	152166234 - 152451358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011677 (version 83.38)
Entrez gene	2556
UniProt	P34903 (UniProt - Evidence at transcript level)
neXtProt	NX_P34903
Antibodypedia	GABRA3 antibodies

PROTEIN BROWSER

GABRA3-001	GABRA3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABRA3-001 ENSP00000359337 ENST00000370314	P34903 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005237 [inhibitory extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0008503 [benzodiazepine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0042493 [response to drug] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	492 aa 55.2 kDa	Yes	4
GABRA3-005 ENSP00000443527 ENST00000535043	P34903 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005237 [inhibitory extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0008503 [benzodiazepine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0042493 [response to drug] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	492 aa 55.2 kDa	Yes	4