Cell atlas - SEMA3B - The Human Protein Atlas

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SEMA3B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SEMA3B
Gene description	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (WM-115, Hep G2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SEMA3B (HGNC Symbol)
Synonyms	LUCA-1, SemA, sema5, SEMAA, semaV
Description	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	50267558 - 50277546
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000012171 (version 83.38)
Entrez gene	7869
UniProt	Q13214 (UniProt - Evidence at transcript level)
neXtProt	NX_Q13214
Antibodypedia	SEMA3B antibodies

PROTEIN BROWSER

SEMA3B-001	SEMA3B-005	SEMA3B-007	SEMA3B-009	SEMA3B-010	SEMA3B-016	SEMA3B-201	SEMA3B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEMA3B-001 ENSP00000484146 ENST00000616701	Q13214 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0038191 [neuropilin binding] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0070062 [extracellular exosome] GO:0071526 [semaphorin-plexin signaling pathway] Show all	749 aa 83.1 kDa	Yes	0
SEMA3B-005 ENSP00000485646 ENST00000456560	B4DEK9 [Direct mapping] Semaphorin-3B; cDNA FLJ55830, highly similar to Semaphorin-3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	406 aa 45 kDa	No	0
SEMA3B-007 ENSP00000485173 ENST00000418576	B4DEK9 [Direct mapping] Semaphorin-3B; cDNA FLJ55830, highly similar to Semaphorin-3B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	406 aa 45 kDa	No	0
SEMA3B-009 ENSP00000480680 ENST00000611067	A0A0C4DGV8 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	754 aa 83.7 kDa	Yes	0
SEMA3B-010 ENSP00000482586 ENST00000621029	A0A087WZE0 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	214 aa 23.5 kDa	Yes	0
SEMA3B-016 ENSP00000485281 ENST00000433753	Q13214 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0038191 [neuropilin binding] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0070062 [extracellular exosome] GO:0071526 [semaphorin-plexin signaling pathway] Show all	748 aa 83 kDa	Yes	0
SEMA3B-201 ENSP00000484583 ENST00000611418	Q9HBR1 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	457 aa 50.4 kDa	Yes	0
SEMA3B-202 ENSP00000481957 ENST00000618865	Q13214 [Direct mapping] Semaphorin-3B Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0038191 [neuropilin binding] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0070062 [extracellular exosome] GO:0071526 [semaphorin-plexin signaling pathway] Show all	749 aa 83.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.