Cell atlas - PRICKLE3 - The Human Protein Atlas

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PRICKLE3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleus
	Plasma membrane

Human cell
	Centrosome
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PRICKLE3
Gene description	Prickle homolog 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus, plasma membrane & centrosome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Plasma membrane (approved), Centrosome (approved)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001442
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ASSAYS

RNA expression

Human cells

GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus, plasma membrane & centrosome.

Main location

Nucleus (approved), Plasma membrane (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA001442	A-431	Nucleoplasm
HPA001442	A-431	Centrosome
HPA001442	U-2 OS	Nucleus
HPA001442	U-2 OS	Centrosome
HPA001442	U-251 MG	Nucleus
HPA001442	U-251 MG	Centrosome

GFP

Antibody	HPA001442
Validation	N-terminal tag BAC cell line: 3564 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA001442	HeLa	3564	N-terminal	Plasma membrane, Centrosome	Plasma membrane
	HPA001442	HeLa	Normal	-	Centrosome	-

GENE INFORMATION
Gene name	PRICKLE3 (HGNC Symbol)
Synonyms	LMO6
Description	Prickle homolog 3 (HGNC Symbol)
Entrez gene summary	LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49175264 - 49186528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000012211 (version 83.38)
Entrez gene	4007
UniProt	O43900 (UniProt - Evidence at protein level)
neXtProt	NX_O43900
Antibodypedia	PRICKLE3 antibodies

PROTEIN BROWSER

PRICKLE3-001	PRICKLE3-003	PRICKLE3-004	PRICKLE3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRICKLE3-001 ENSP00000388599 ENST00000453382	H0Y413 [Direct mapping] Prickle-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	547 aa 60.8 kDa	No	0
PRICKLE3-003 ENSP00000470248 ENST00000599218	O43900 [Direct mapping] Prickle-like protein 3 A0A024QYW5 [Target identity:100%; Query identity:100%] LIM domain only 6, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] Show all	615 aa 68.6 kDa	No	0
PRICKLE3-004 ENSP00000390620 ENST00000432913	H7BZP7 [Direct mapping] Prickle-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	252 aa 28.6 kDa	No	0
PRICKLE3-009 ENSP00000365494 ENST00000376317	A0A0A0MRT7 [Direct mapping] Prickle-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	114 aa 13 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.