Fields »
ABOUT
HELP
BLOG
ALOX5

CANCER ATLAS

Gene description

 Arachidonate 5-lipoxygenase

Protein class

 Enzymes, FDA approved drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA071285

GENE INFORMATION

Gene name

 ALOX5 (HGNC Symbol)

Synonyms

 5-LOX

Description

 Arachidonate 5-lipoxygenase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 10

Cytoband

 q11.21

Chromosome location (bp)

 45374176 - 45446119

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012779 (version 83.38)

Entrez gene

 240

UniProt

 P09917 (UniProt - Evidence at protein level)

neXtProt

 NX_P09917

Antibodypedia

 ALOX5 antibodies

PROTEIN BROWSER
ALOX5-001
ALOX5-201
ALOX5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOX5-001
ENSP00000363512
ENST00000374391
P09917 [Direct mapping]
Arachidonate 5-lipoxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002526 [acute inflammatory response]
GO:0002540 [leukotriene production involved in inflammatory response]
GO:0004051 [arachidonate 5-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0007584 [response to nutrient]
GO:0016363 [nuclear matrix]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019233 [sensory perception of pain]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0019372 [lipoxygenase pathway]
GO:0030425 [dendrite]
GO:0031965 [nuclear membrane]
GO:0042383 [sarcolemma]
GO:0044281 [small molecule metabolic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046872 [metal ion binding]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:2001300 [lipoxin metabolic process]
Show all
 674 aa
78 kDa 		No 0
ALOX5-201
ENSP00000437634
ENST00000542434
P09917 [Direct mapping]
Arachidonate 5-lipoxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004051 [arachidonate 5-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005635 [nuclear envelope]
GO:0005641 [nuclear envelope lumen]
GO:0005829 [cytosol]
GO:0006691 [leukotriene metabolic process]
GO:0016363 [nuclear matrix]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0019372 [lipoxygenase pathway]
GO:0031965 [nuclear membrane]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:2001300 [lipoxin metabolic process]
Show all
 617 aa
71.6 kDa 		No 0
ALOX5-202
ENSP00000483803
ENST00000612635
A0A087X109 [Direct mapping]
Arachidonate 5-lipoxygenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 139 aa
16.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.