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PGM3

GENERAL INFORMATION

Gene name

 PGM3

Gene description

 Phosphoglucomutase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several tissues, most abundant in prostate and placenta.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA029759 , HPA029760 , CAB004998
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PGM3 (HGNC Symbol)

Synonyms

 AGM1, DKFZP434B187, PAGM

Description

 Phosphoglucomutase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 83161150 - 83193936

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013375 (version 83.38)

Entrez gene

 5238

UniProt

 O95394 (UniProt - Evidence at protein level)

neXtProt

 NX_O95394

Antibodypedia

 PGM3 antibodies

PROTEIN BROWSER
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PGM3-001
PGM3-002
PGM3-003
PGM3-004
PGM3-005
PGM3-006
PGM3-007
PGM3-009
PGM3-014
PGM3-015
PGM3-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGM3-001
ENSP00000424874
ENST00000513973
O95394 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004610 [phosphoacetylglucosamine mutase activity]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006041 [glucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006493 [protein O-linked glycosylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030097 [hemopoiesis]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0071704 [organic substance metabolic process]
Show all
 542 aa
59.9 kDa 		No 0
PGM3-002
ENSP00000425809
ENST00000506587
O95394 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004610 [phosphoacetylglucosamine mutase activity]
GO:0004614 [phosphoglucomutase activity]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006041 [glucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006493 [protein O-linked glycosylation]
GO:0007283 [spermatogenesis]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019255 [glucose 1-phosphate metabolic process]
GO:0030097 [hemopoiesis]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0071704 [organic substance metabolic process]
Show all
 570 aa
62.9 kDa 		No 0
PGM3-003
ENSP00000283977
ENST00000283977
J3KN95 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004610 [phosphoacetylglucosamine mutase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
GO:0071704 [organic substance metabolic process]
Show all
 461 aa
51.1 kDa 		No 0
PGM3-004
ENSP00000421565
ENST00000512866
O95394 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004610 [phosphoacetylglucosamine mutase activity]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006041 [glucosamine metabolic process]
GO:0006048 [UDP-N-acetylglucosamine biosynthetic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006493 [protein O-linked glycosylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030097 [hemopoiesis]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0071704 [organic substance metabolic process]
Show all
 566 aa
62.3 kDa 		No 0
PGM3-005
ENSP00000425558
ENST00000507554
D6RCQ8 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
Show all
 147 aa
16.1 kDa 		No 0
PGM3-006
ENSP00000424865
ENST00000508748
D6RF77 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
Show all
 157 aa
17.3 kDa 		No 0
PGM3-007
ENSP00000422362
ENST00000503094
D6RC77 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
Show all
 114 aa
12.4 kDa 		No 0
PGM3-009
ENSP00000427420
ENST00000510258
D6RIS6 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
Show all
 173 aa
19.2 kDa 		No 0
PGM3-014
ENSP00000423389
ENST00000509219
H0Y987 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
GO:0071704 [organic substance metabolic process]
Show all
 197 aa
21.8 kDa 		No 0
PGM3-015
ENSP00000474029
ENST00000605602
S4R390 [Direct mapping]
Phosphoacetylglucosamine mutase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0030097 [hemopoiesis]
Show all
 11 aa
1.2 kDa 		No 0
PGM3-201
ENSP00000477539
ENST00000616566
A0A087WT27 [Direct mapping]
Phosphoacetylglucosamine mutase; Phosphoglucomutase 3, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004610 [phosphoacetylglucosamine mutase activity]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0030097 [hemopoiesis]
GO:0071704 [organic substance metabolic process]
Show all
 441 aa
49.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.