Expression of CLK1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

CDC-like kinase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB033141

GENE INFORMATION
Gene name	CLK1
Synonyms
Description	CDC-like kinase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	200853009 - 200864744
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013441 (version 83.38)
Entrez gene	1195
UniProt	P49759 (UniProt - Evidence at protein level)
neXtProt	NX_P49759
Antibodypedia	CLK1 antibodies

PROTEIN BROWSER

CLK1-001	CLK1-005	CLK1-007	CLK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLK1-001 ENSP00000326830 ENST00000321356	P49759 [Direct mapping] Dual specificity protein kinase CLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0043484 [regulation of RNA splicing] Show all	484 aa 57.3 kDa	No	1
CLK1-005 ENSP00000386358 ENST00000409769	B8ZZR0 [Direct mapping] Dual-specificity protein kinase CLK1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	307 aa 36.3 kDa	No	0
CLK1-007 ENSP00000394734 ENST00000434813	P49759 [Direct mapping] Dual specificity protein kinase CLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043484 [regulation of RNA splicing] GO:0046777 [protein autophosphorylation] Show all	526 aa 61.8 kDa	No	1
CLK1-201 ENSP00000479484 ENST00000621181	A0A087WVK0 [Direct mapping] Dual-specificity protein kinase CLK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	454 aa 53.8 kDa	No	1