Cell atlas - POLR3B - The Human Protein Atlas

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POLR3B

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POLR3B
Gene description	Polymerase (RNA) III (DNA directed) polypeptide B
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036466
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036466	A-431	Nuclear speckles
	HPA036466	U-2 OS	Nuclear speckles
	HPA036466	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	POLR3B (HGNC Symbol)
Synonyms	FLJ10388, RPC2
Description	Polymerase (RNA) III (DNA directed) polypeptide B (HGNC Symbol)
Entrez gene summary	This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	106357658 - 106510198
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013503 (version 83.38)
Entrez gene	55703
UniProt	Q9NW08 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NW08
Antibodypedia	POLR3B antibodies

PROTEIN BROWSER

POLR3B-001	POLR3B-003	POLR3B-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR3B-001 ENSP00000228347 ENST00000228347	Q9NW08 [Direct mapping] DNA-directed RNA polymerase III subunit RPC2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032549 [ribonucleoside binding] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus] Show all	1133 aa 127.8 kDa	No	0
POLR3B-003 ENSP00000445721 ENST00000539066	Q9NW08 [Direct mapping] DNA-directed RNA polymerase III subunit RPC2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0032481 [positive regulation of type I interferon production] GO:0032549 [ribonucleoside binding] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus] Show all	1075 aa 121.1 kDa	No	0
POLR3B-004 ENSP00000448398 ENST00000549569	F8VRU2 [Direct mapping] DNA-directed RNA polymerase III subunit RPC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0032549 [ribonucleoside binding] Show all	170 aa 19.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.