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DDX11

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GENERAL INFORMATION

Gene name

 DDX11

Gene description

 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA065197
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

 Nucleus (supported)

Additional location

 Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA065197 HEK 293 Nucleus
HPA065197 HeLa Nucleus
Nucleoli fibrillar center
HPA065197 U-2 OS Nucleus Intensity
Nucleoli Intensity

GENE INFORMATION

Gene name

 DDX11 (HGNC Symbol)

Synonyms

 CHL1, CHLR1, KRG2, WABS

Description

 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p11.21

Chromosome location (bp)

 31073845 - 31104791

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000013573 (version 83.38)

Entrez gene

 1663

UniProt

 Q96FC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96FC9

Antibodypedia

 DDX11 antibodies

PROTEIN BROWSER
DDX11-001
DDX11-003
DDX11-006
DDX11-010
DDX11-015
DDX11-016
DDX11-019
DDX11-020
DDX11-030

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX11-001
ENSP00000443426
ENST00000542838
Q96FC9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000922 [spindle pole]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007062 [sister chromatid cohesion]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032508 [DNA duplex unwinding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 906 aa
101.7 kDa 		No 0
DDX11-003
ENSP00000440402
ENST00000545668
Q96FC9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000922 [spindle pole]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007062 [sister chromatid cohesion]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032508 [DNA duplex unwinding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 970 aa
108.3 kDa 		No 0
DDX11-006
ENSP00000228264
ENST00000228264
Q96FC9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000922 [spindle pole]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007062 [sister chromatid cohesion]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032508 [DNA duplex unwinding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 880 aa
98.7 kDa 		No 0
DDX11-010
ENSP00000309965
ENST00000350437
Q96FC9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000922 [spindle pole]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0007062 [sister chromatid cohesion]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032508 [DNA duplex unwinding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
 856 aa
96.1 kDa 		No 0
DDX11-015
ENSP00000440171
ENST00000535317
F5GXL6 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 192 aa
21.5 kDa 		No 0
DDX11-016
ENSP00000406457
ENST00000415475
F5GXJ8 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 224 aa
25.9 kDa 		No 0
DDX11-019
ENSP00000407646
ENST00000438391
C9K0E8 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 302 aa
34.6 kDa 		No 0
DDX11-020
ENSP00000473610
ENST00000544652
R4GNE1 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 91 aa
9.9 kDa 		No 0
DDX11-030
ENSP00000441015
ENST00000539702
H0YFY8 [Direct mapping]
Probable ATP-dependent RNA helicase DDX11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0008026 [ATP-dependent helicase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 172 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.