Expression of CAPN1 in cancer - Summary

CANCER ATLAS

Gene description

Calpain 1, (mu/I) large subunit

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005992

GENE INFORMATION
Gene name	CAPN1 (HGNC Symbol)
Synonyms	CANP, CANPL1, muCANP, muCL
Description	Calpain 1, (mu/I) large subunit (HGNC Symbol)
Entrez gene summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65180566 - 65212006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000014216 (version 83.38)
Entrez gene	823
UniProt	P07384 (UniProt - Evidence at protein level)
neXtProt	NX_P07384
Antibodypedia	CAPN1 antibodies

PROTEIN BROWSER

CAPN1-001	CAPN1-002	CAPN1-003	CAPN1-004	CAPN1-009	CAPN1-010	CAPN1-011	CAPN1-012	CAPN1-013	CAPN1-015	CAPN1-017	CAPN1-026	CAPN1-027	CAPN1-028	CAPN1-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN1-001 ENSP00000435272 ENST00000533820	P07384 [Direct mapping] Calpain-1 catalytic subunit Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	714 aa 81.9 kDa	No	0
CAPN1-002 ENSP00000434176 ENST00000524773	P07384 [Direct mapping] Calpain-1 catalytic subunit Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	714 aa 81.9 kDa	No	0
CAPN1-003 ENSP00000279247 ENST00000279247	P07384 [Direct mapping] Calpain-1 catalytic subunit Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	714 aa 81.9 kDa	No	0
CAPN1-004 ENSP00000431984 ENST00000527323	P07384 [Direct mapping] Calpain-1 catalytic subunit Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008092 [cytoskeletal protein binding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0032801 [receptor catabolic process] GO:0060056 [mammary gland involution] GO:0070062 [extracellular exosome] Show all	714 aa 81.9 kDa	No	0
CAPN1-009 ENSP00000433823 ENST00000527739	E9PJA6 [Direct mapping] Calpain-1 catalytic subunit Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	162 aa 18.2 kDa	No	0
CAPN1-010 ENSP00000431793 ENST00000534373	E9PJJ3 [Direct mapping] Calpain-1 catalytic subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	136 aa 15.1 kDa	No	0
CAPN1-011 ENSP00000436693 ENST00000532285	E9PIA9 [Direct mapping] Calpain-1 catalytic subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] Show all	63 aa 7.2 kDa	No	0
CAPN1-012 ENSP00000435092 ENST00000531068	E9PLX0 [Direct mapping] Calpain-1 catalytic subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	122 aa 13.6 kDa	No	0
CAPN1-013 ENSP00000431172 ENST00000527699	E9PMC6 [Direct mapping] Calpain-1 catalytic subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	152 aa 16.9 kDa	No	0
CAPN1-015 ENSP00000433366 ENST00000526468	E9PL37 [Direct mapping] Calpain-1 catalytic subunit Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	191 aa 21.1 kDa	No	0
CAPN1-017 ENSP00000431528 ENST00000526966	E9PJA6 [Direct mapping] Calpain-1 catalytic subunit Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	162 aa 18.2 kDa	No	0
CAPN1-026 ENSP00000435847 ENST00000528396	E9PSA6 [Direct mapping] Calpain-1 catalytic subunit Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	163 aa 18.3 kDa	No	0
CAPN1-027 ENSP00000432512 ENST00000529133	E9PQB3 [Direct mapping] Calpain-1 catalytic subunit Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	191 aa 21.4 kDa	No	0
CAPN1-028 ENSP00000431686 ENST00000533129	P07384 [Direct mapping] Calpain-1 catalytic subunit Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	714 aa 81.9 kDa	No	0
CAPN1-029 ENSP00000435198 ENST00000533909	E9PLC9 [Direct mapping] Calpain-1 catalytic subunit Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	148 aa 16.4 kDa	No	0