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DPEP1

GENERAL INFORMATION

Gene name

 DPEP1

Gene description

 Dipeptidase 1 (renal)

Protein class

 Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine, kidney)
GTEx:Tissue enhanced (small intestine, pancreas)
FANTOM5:Group enriched (small intestine, pancreas, colon, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and luminal expression in a group of tissues, including kidney, gastrointestinal tract and pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA009426 , HPA012783
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, pancreas, colon, kidney)

GENE INFORMATION

Gene name

 DPEP1

Synonyms

Description

 Dipeptidase 1 (renal) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 16

Cytoband

 q24.3

Chromosome location (bp)

 89613308 - 89638456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000015413 (version 83.38)

Entrez gene

 1800

UniProt

 P16444 (UniProt - Evidence at protein level)

neXtProt

 NX_P16444

Antibodypedia

 DPEP1 antibodies

PROTEIN BROWSER
DPEP1-001
DPEP1-002
DPEP1-005
DPEP1-008
DPEP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPEP1-001
ENSP00000261615
ENST00000261615
P16444 [Direct mapping]
Dipeptidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008235 [metalloexopeptidase activity]
GO:0008239 [dipeptidyl-peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016324 [apical plasma membrane]
GO:0016805 [dipeptidase activity]
GO:0016999 [antibiotic metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0030054 [cell junction]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0031528 [microvillus membrane]
GO:0034235 [GPI anchor binding]
GO:0035690 [cellular response to drug]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0050667 [homocysteine metabolic process]
GO:0070062 [extracellular exosome]
GO:0070573 [metallodipeptidase activity]
GO:0071277 [cellular response to calcium ion]
GO:0071732 [cellular response to nitric oxide]
GO:0072340 [cellular lactam catabolic process]
GO:0072341 [modified amino acid binding]
Show all
 411 aa
45.7 kDa 		Yes 0
DPEP1-002
ENSP00000376807
ENST00000393092
P16444 [Direct mapping]
Dipeptidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008235 [metalloexopeptidase activity]
GO:0008239 [dipeptidyl-peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016324 [apical plasma membrane]
GO:0016805 [dipeptidase activity]
GO:0016999 [antibiotic metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0030054 [cell junction]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0031528 [microvillus membrane]
GO:0034235 [GPI anchor binding]
GO:0035690 [cellular response to drug]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0050667 [homocysteine metabolic process]
GO:0070062 [extracellular exosome]
GO:0070573 [metallodipeptidase activity]
GO:0071277 [cellular response to calcium ion]
GO:0071732 [cellular response to nitric oxide]
GO:0072340 [cellular lactam catabolic process]
GO:0072341 [modified amino acid binding]
Show all
 411 aa
45.7 kDa 		Yes 0
DPEP1-005
ENSP00000455916
ENST00000570029
H3BQS5 [Direct mapping]
Dipeptidase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0016805 [dipeptidase activity]
GO:0031225 [anchored component of membrane]
GO:0046872 [metal ion binding]
Show all
 107 aa
12.5 kDa 		Yes 0
DPEP1-008
ENSP00000455142
ENST00000568281
H3BP43 [Direct mapping]
Dipeptidase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0016805 [dipeptidase activity]
GO:0031225 [anchored component of membrane]
GO:0046872 [metal ion binding]
Show all
 111 aa
13 kDa 		Yes 0
DPEP1-201
ENSP00000397313
ENST00000421184
P16444 [Direct mapping]
Dipeptidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008235 [metalloexopeptidase activity]
GO:0008239 [dipeptidyl-peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016324 [apical plasma membrane]
GO:0016805 [dipeptidase activity]
GO:0016999 [antibiotic metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0030054 [cell junction]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0031528 [microvillus membrane]
GO:0034235 [GPI anchor binding]
GO:0035690 [cellular response to drug]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0050667 [homocysteine metabolic process]
GO:0070062 [extracellular exosome]
GO:0070573 [metallodipeptidase activity]
GO:0071277 [cellular response to calcium ion]
GO:0071732 [cellular response to nitric oxide]
GO:0072340 [cellular lactam catabolic process]
GO:0072341 [modified amino acid binding]
Show all
 411 aa
45.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.