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Most cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in many cases. Several lymphomas, gliomas, renal cell carcinomas and hepatocellular carcinomas were negative.
Few cases of lung, liver and breast cancers displayed moderate to strong cytoplasmic staining with additional nuclear positivity in carcinoids. Remaining cancer tissues were weakly stained or negative.
Several cases of liver cancers as well as cases of melanomas, endometrial, ovarian, renal and lung cancers showed moderate cytoplasmic staining. A subset of tumor cells in renal cancers displayed moderate nuclear membranous staining. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
RGPD5 (HGNC Symbol)
Synonyms
BS-63, DKFZp686I1842, RGP5
Description
RANBP2-like and GRIP domain containing 5 (HGNC Symbol)
Entrez gene summary
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008]
