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Gene name

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Reliability

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Validation

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Method

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Cell type

Expression

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Detectable

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Detectable

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ISL1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ISL1

Gene description

ISL LIM homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (seminal vesicle, prostate, placenta, stomach)
GTEx:Tissue enhanced (vagina, prostate)
FANTOM5:Tissue enhanced (seminal vesicle, cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in few tissues.

DATA RELIABILITY

Data reliability
description

Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA057416
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, prostate, placenta, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (vagina, prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, cervix, uterine)

GENE INFORMATION

Gene name

ISL1 (HGNC Symbol)

Synonyms

Isl-1, ISLET1

Description

ISL LIM homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q11.1

Chromosome location (bp)

51383391 - 51394738

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000016082 (version 83.38)

Entrez gene

3670

UniProt

P61371 (UniProt - Evidence at protein level)

neXtProt

NX_P61371

Antibodypedia

ISL1 antibodies

PROTEIN BROWSER

ISL1-001
ISL1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ISL1-001
ENSP00000230658
ENST00000230658
P61371 [Direct mapping]
Insulin gene enhancer protein ISL-1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001755 [neural crest cell migration]
GO:0003007 [heart morphogenesis]
GO:0003139 [secondary heart field specification]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003266 [regulation of secondary heart field cardioblast proliferation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0021520 [spinal cord motor neuron cell fate specification]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021524 [visceral motor neuron differentiation]
GO:0021559 [trigeminal nerve development]
GO:0021983 [pituitary gland development]
GO:0030182 [neuron differentiation]
GO:0030331 [estrogen receptor binding]
GO:0031016 [pancreas development]
GO:0031103 [axon regeneration]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0032024 [positive regulation of insulin secretion]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032730 [positive regulation of interleukin-1 alpha production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043388 [positive regulation of DNA binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0048665 [neuron fate specification]
GO:0048762 [mesenchymal cell differentiation]
GO:0048880 [sensory system development]
GO:0048935 [peripheral nervous system neuron development]
GO:0048936 [peripheral nervous system neuron axonogenesis]
GO:0050728 [negative regulation of inflammatory response]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060037 [pharyngeal system development]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060384 [innervation]
GO:0060413 [atrial septum morphogenesis]
GO:0060913 [cardiac cell fate determination]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071657 [positive regulation of granulocyte colony-stimulating factor production]
GO:0090074 [negative regulation of protein homodimerization activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1901258 [positive regulation of macrophage colony-stimulating factor production]
Show all
349 aa
39 kDa
No 0
ISL1-003
ENSP00000422676
ENST00000511384
D6RBJ1 [Direct mapping]
Insulin gene enhancer protein ISL-1
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
326 aa
36.7 kDa
No 0

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