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ATP2C1

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GENERAL INFORMATION

Gene name

 ATP2C1

Gene description

 ATPase, Ca++ transporting, type 2C, member 1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA069684
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus.

Main location

 Golgi apparatus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA069684 HaCaT Golgi apparatus
HPA069684 U-2 OS Golgi apparatus

GENE INFORMATION

Gene name

 ATP2C1 (HGNC Symbol)

Synonyms

 ATP2C1A, BCPM, KIAA1347, PMR1, SPCA1

Description

 ATPase, Ca++ transporting, type 2C, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 130850595 - 131016712

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000017260 (version 83.38)

Entrez gene

 27032

UniProt

 P98194 (UniProt - Evidence at protein level)

neXtProt

 NX_P98194

Antibodypedia

 ATP2C1 antibodies

PROTEIN BROWSER
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ATP2C1-001
ATP2C1-002
ATP2C1-003
ATP2C1-004
ATP2C1-005
ATP2C1-006
ATP2C1-007
ATP2C1-008
ATP2C1-009
ATP2C1-010
ATP2C1-011
ATP2C1-014
ATP2C1-015
ATP2C1-017
ATP2C1-019
ATP2C1-020
ATP2C1-021
ATP2C1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP2C1-001
ENSP00000424783
ENST00000508532
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 919 aa
100.6 kDa 		No >9
ATP2C1-002
ENSP00000329664
ENST00000328560
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 888 aa
97 kDa 		No 9
ATP2C1-003
ENSP00000422872
ENST00000513801
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 923 aa
101.2 kDa 		No >9
ATP2C1-004
ENSP00000423330
ENST00000504948
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 903 aa
98.7 kDa 		No >9
ATP2C1-005
ENSP00000352665
ENST00000359644
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 949 aa
104 kDa 		No >9
ATP2C1-006
ENSP00000425228
ENST00000504612
H0Y9V7 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 903 aa
98.9 kDa 		No >9
ATP2C1-007
ENSP00000425320
ENST00000504381
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 944 aa
103.5 kDa 		No >9
ATP2C1-008
ENSP00000427461
ENST00000510168
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 919 aa
100.6 kDa 		No >9
ATP2C1-009
ENSP00000423774
ENST00000505330
B4E2Q0 [Direct mapping]
Calcium-transporting ATPase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0006816 [calcium ion transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 953 aa
104.7 kDa 		No >9
ATP2C1-010
ENSP00000421326
ENST00000507488
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 973 aa
107.1 kDa 		No >9
ATP2C1-011
ENSP00000395809
ENST00000428331
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 919 aa
100.6 kDa 		No >9
ATP2C1-014
ENSP00000426849
ENST00000509662
D6REJ1 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 102 aa
11.6 kDa 		No 1
ATP2C1-015
ENSP00000421261
ENST00000508297
D6RGE9 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 82 aa
9.3 kDa 		No 1
ATP2C1-017
ENSP00000424930
ENST00000508660
H0Y9S7 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 314 aa
34.8 kDa 		No 3
ATP2C1-019
ENSP00000422890
ENST00000515854
D6R9U9 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]
Show all
 131 aa
14 kDa 		No 2
ATP2C1-020
ENSP00000402677
ENST00000422190
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 939 aa
103 kDa 		No >9
ATP2C1-021
ENSP00000427625
ENST00000505072
D6RHV9 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 120 aa
13.5 kDa 		No 2
ATP2C1-201
ENSP00000432956
ENST00000533801
P98194 [Direct mapping]
Calcium-transporting ATPase type 2C member 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0004871 [signal transducer activity]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0015410 [manganese-transporting ATPase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0030026 [cellular manganese ion homeostasis]
GO:0030145 [manganese ion binding]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032468 [Golgi calcium ion homeostasis]
GO:0032472 [Golgi calcium ion transport]
GO:0034220 [ion transmembrane transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071421 [manganese ion transmembrane transport]
Show all
 888 aa
97 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.