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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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IGF1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IGF1

Gene description

Insulin-like growth factor 1 (somatomedin C)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cervix, uterine)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Extracellular deposits and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Approved based on 1 antibody.
HPA048946
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

IGF1 (HGNC Symbol)

Synonyms

IGF-I, IGF1A, IGFI

Description

Insulin-like growth factor 1 (somatomedin C) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Chromosome

12

Cytoband

q23.2

Chromosome location (bp)

102395867 - 102480645

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000017427 (version 83.38)

Entrez gene

3479

UniProt

P05019 (UniProt - Evidence at protein level)

neXtProt

NX_P05019

Antibodypedia

IGF1 antibodies

PROTEIN BROWSER

IGF1-001
IGF1-002
IGF1-003
IGF1-004
IGF1-005
IGF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF1-001
ENSP00000337612
ENST00000337514
P05019 [Direct mapping]
Insulin-like growth factor I
Q5U743 [Target identity:100%; Query identity:100%]
Insulin-like growth factor 1 (Somatomedin C); Insulin-like growth factor 1 (Somatomedin C), isoform CRA_d
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001775 [cell activation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0009441 [glycolate metabolic process]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration]
GO:0014896 [muscle hypertrophy]
GO:0014904 [myotube cell development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045445 [myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051450 [myoblast proliferation]
GO:0060283 [negative regulation of oocyte development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1904075 [positive regulation of trophectodermal cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
153 aa
17 kDa
Yes 0
IGF1-002
ENSP00000302665
ENST00000307046
P05019 [Direct mapping]
Insulin-like growth factor I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001666 [response to hypoxia]
GO:0001775 [cell activation]
GO:0001932 [regulation of protein phosphorylation]
GO:0001974 [blood vessel remodeling]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005179 [hormone activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005614 [interstitial matrix]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006417 [regulation of translation]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007517 [muscle organ development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0007613 [memory]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0009441 [glycolate metabolic process]
GO:0009612 [response to mechanical stimulus]
GO:0010001 [glial cell differentiation]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration]
GO:0014896 [muscle hypertrophy]
GO:0014904 [myotube cell development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0021940 [positive regulation of cerebellar granule cell precursor proliferation]
GO:0030104 [water homeostasis]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030168 [platelet activation]
GO:0030307 [positive regulation of cell growth]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030879 [mammary gland development]
GO:0031000 [response to caffeine]
GO:0031017 [exocrine pancreas development]
GO:0031093 [platelet alpha granule lumen]
GO:0031667 [response to nutrient levels]
GO:0032496 [response to lipopolysaccharide]
GO:0032869 [cellular response to insulin stimulus]
GO:0032878 [regulation of establishment or maintenance of cell polarity]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0035094 [response to nicotine]
GO:0035264 [multicellular organism growth]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042127 [regulation of cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045445 [myoblast differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048286 [lung alveolus development]
GO:0048468 [cell development]
GO:0048545 [response to steroid hormone]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048839 [inner ear development]
GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0050974 [detection of mechanical stimulus involved in sensory perception]
GO:0051246 [regulation of protein metabolic process]
GO:0051384 [response to glucocorticoid]
GO:0051450 [myoblast proliferation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051924 [regulation of calcium ion transport]
GO:0060283 [negative regulation of oocyte development]
GO:0060426 [lung vasculature development]
GO:0060463 [lung lobe morphogenesis]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060736 [prostate gland growth]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0060741 [prostate gland stromal morphogenesis]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071257 [cellular response to electrical stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1901215 [negative regulation of neuron death]
GO:1904075 [positive regulation of trophectodermal cell proliferation]
GO:1904193 [negative regulation of cholangiocyte apoptotic process]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
GO:2000288 [positive regulation of myoblast proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
195 aa
21.8 kDa
Yes 0
IGF1-003
ENSP00000376638
ENST00000392905
Q13429 [Direct mapping]
Insulin-like growth factor I; Insulin-like growth factor-I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0030166 [proteoglycan biosynthetic process]
GO:0050714 [positive regulation of protein secretion]
GO:0050821 [protein stabilization]
GO:0060283 [negative regulation of oocyte development]
Show all
139 aa
15.6 kDa
Yes 0
IGF1-004
ENSP00000416811
ENST00000424202
P05019 [Direct mapping]
Insulin-like growth factor I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001775 [cell activation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0009441 [glycolate metabolic process]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration]
GO:0014896 [muscle hypertrophy]
GO:0014904 [myotube cell development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045445 [myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051450 [myoblast proliferation]
GO:0060283 [negative regulation of oocyte development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1904075 [positive regulation of trophectodermal cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
137 aa
15.2 kDa
Yes 0
IGF1-005
ENSP00000376637
ENST00000392904
P05019 [Direct mapping]
Insulin-like growth factor I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001775 [cell activation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0009441 [glycolate metabolic process]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration]
GO:0014896 [muscle hypertrophy]
GO:0014904 [myotube cell development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045445 [myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051450 [myoblast proliferation]
GO:0060283 [negative regulation of oocyte development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1904075 [positive regulation of trophectodermal cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
158 aa
17.8 kDa
Yes 0
IGF1-201
ENSP00000394999
ENST00000456098
P05019 [Direct mapping]
Insulin-like growth factor I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001775 [cell activation]
GO:0002576 [platelet degranulation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007517 [muscle organ development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009408 [response to heat]
GO:0009441 [glycolate metabolic process]
GO:0010468 [regulation of gene expression]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration]
GO:0014896 [muscle hypertrophy]
GO:0014904 [myotube cell development]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0040014 [regulation of multicellular organism growth]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043491 [protein kinase B signaling]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045445 [myoblast differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045821 [positive regulation of glycolytic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051450 [myoblast proliferation]
GO:0060283 [negative regulation of oocyte development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1904075 [positive regulation of trophectodermal cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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158 aa
17.8 kDa
Yes 0

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