Expression of CNTN1 in cancer - Summary - The Human Protein Atlas

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CNTN1

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Contactin 1

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA041060	CAB025200

GENE INFORMATION
Gene name	CNTN1 (HGNC Symbol)
Synonyms	F3, GP135
Description	Contactin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	40692442 - 41072418
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000018236 (version 83.38)
Entrez gene	1272
UniProt	Q12860 (UniProt - Evidence at protein level)
neXtProt	NX_Q12860
Antibodypedia	CNTN1 antibodies

PROTEIN BROWSER

CNTN1-001	CNTN1-002	CNTN1-003	CNTN1-004	CNTN1-005	CNTN1-006	CNTN1-007	CNTN1-008	CNTN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTN1-001 ENSP00000447006 ENST00000551295	Q12860 [Direct mapping] Contactin-1 A0A024R104 [Target identity:100%; Query identity:100%] Contactin 1, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0010628 [positive regulation of gene expression] GO:0010765 [positive regulation of sodium ion transport] GO:0010976 [positive regulation of neuron projection development] GO:0016020 [membrane] GO:0021549 [cerebellum development] GO:0030246 [carbohydrate binding] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0043209 [myelin sheath] GO:0045121 [membrane raft] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0070062 [extracellular exosome] Show all	1018 aa 113.3 kDa	Yes	0
CNTN1-002 ENSP00000261160 ENST00000348761	Q12860 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	1007 aa 111.9 kDa	Yes	0
CNTN1-003 ENSP00000448004 ENST00000547702	Q12860 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	627 aa 70.6 kDa	Yes	0
CNTN1-004 ENSP00000448653 ENST00000547849	Q12860 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	627 aa 70.6 kDa	Yes	0
CNTN1-005 ENSP00000450412 ENST00000551424	F8VQW3 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.3 kDa	Yes	0
CNTN1-006 ENSP00000449706 ENST00000552913	F8VX96 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.4 kDa	Yes	0
CNTN1-007 ENSP00000447860 ENST00000552248	F8VUI9 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.4 kDa	Yes	0
CNTN1-008 ENSP00000447862 ENST00000548005	F8VUI8 [Direct mapping] Contactin-1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.9 kDa	Yes	0
CNTN1-201 ENSP00000325660 ENST00000347616	Q12860 [Direct mapping] Contactin-1 A0A024R104 [Target identity:100%; Query identity:100%] Contactin 1, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	1018 aa 113.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.