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Most tumor types displayed some cases with moderate cytoplasmic staining, however, many cases were negative. Some liver cancers and a few stomach and pancreatic cancers were strongly stained.
Liver cancers exhibited moderate to strong cytoplasmic staining. A majority of colorectal and several cases of endometrial, lung, stomach and pancreatic cancers showed moderate positivity. Remaining malignant cells were weakly stained or negative.
A majority of liver and several endometrial, ovarian, pancreatic, gastric and lung cancers showed moderate positivity. Remaining malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
AGPS (HGNC Symbol)
Synonyms
ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY
Description
Alkylglycerone phosphate synthase (HGNC Symbol)
Entrez gene summary
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
