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MARCO

GENERAL INFORMATION

Gene name

 MARCO

Gene description

 Macrophage receptor with collagenous structure

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lung, appendix)
GTEx:Tissue enhanced (lung, spleen)
FANTOM5:Tissue enhanced (spleen, liver, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in alveolar macrophages and Kupffer cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA063793
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, liver, lung)

GENE INFORMATION

Gene name

 MARCO (HGNC Symbol)

Synonyms

 SCARA2

Description

 Macrophage receptor with collagenous structure (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.2

Chromosome location (bp)

 118942166 - 118994660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000019169 (version 83.38)

Entrez gene

 8685

UniProt

 Q9UEW3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UEW3

Antibodypedia

 MARCO antibodies

PROTEIN BROWSER
MARCO-001
MARCO-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARCO-001
ENSP00000318916
ENST00000327097
Q9UEW3 [Direct mapping]
Macrophage receptor MARCO
Q4ZG40 [Target identity:100%; Query identity:100%]
Macrophage receptor with collagenous structure; Putative uncharacterized protein MARCO; cDNA, FLJ93629, Homo sapiens macrophage receptor with collagenous structure(MARCO), mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002221 [pattern recognition receptor signaling pathway]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005581 [collagen trimer]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0016020 [membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0043277 [apoptotic cell clearance]
GO:0045087 [innate immune response]
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 520 aa
52.7 kDa 		No 1
MARCO-003
ENSP00000409192
ENST00000412481
C9JKT8 [Direct mapping]
Macrophage receptor MARCO
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 64 aa
7.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.