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Cytochrome P450, family 24, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001649 [osteoblast differentiation] GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008403 [25-hydroxycholecalciferol-24-hydroxylase activity] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030342 [1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity] GO:0033280 [response to vitamin D] GO:0042359 [vitamin D metabolic process] GO:0042369 [vitamin D catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070561 [vitamin D receptor signaling pathway]
Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation] GO:0005506 [iron ion binding] GO:0005743 [mitochondrial inner membrane] GO:0006766 [vitamin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030342 [1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity] GO:0033280 [response to vitamin D] GO:0042359 [vitamin D metabolic process] GO:0042369 [vitamin D catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070561 [vitamin D receptor signaling pathway]
