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Malignant cells showed moderate nuclear positivity. Most renal cancers along with several gastric and skin cancers were strongly stained. Several testicular, urothelial and pancreatic cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SNAI2 (HGNC Symbol)
Synonyms
SLUG, SLUGH1, SNAIL2
Description
Snail family zinc finger 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]