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A few cases of colorectal and pancreatic cancers showed weak to moderate cytoplasmic and nuclear staining. Most remaining cancer tissues were negative.
Serpin peptidase inhibitor, clade B (ovalbumin), member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
P30740 [Direct mapping] Leukocyte elastase inhibitor V9HWH1 [Target identity:100%; Query identity:100%] Epididymis luminal protein 57; Serpin peptidase inhibitor, clade B (Ovalbumin), member 1, isoform CRA_a
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
