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CYP3A43
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  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CYP3A43

Gene description

Cytochrome P450, family 3, subfamily A, polypeptide 43

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enhanced (liver, pancreas)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression mainly in liver and kidney

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

Supported based on 1 antibody.
HPA066463
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0510152025TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, pancreas)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05101520Tags Per Million

GENE INFORMATION

Gene name

CYP3A43

Synonyms

Description

Cytochrome P450, family 3, subfamily A, polypeptide 43 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

99828013 - 99866102

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000021461 (version 83.38)

Entrez gene

64816

UniProt

Q9HB55 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HB55

Antibodypedia

CYP3A43 antibodies

PROTEIN BROWSER

CYP3A43-001
CYP3A43-003
CYP3A43-005
CYP3A43-006
CYP3A43-013
CYP3A43-014
CYP3A43-201
CYP3A43-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP3A43-001
ENSP00000346887
ENST00000354829
Q9HB55 [Direct mapping]
Cytochrome P450 3A43
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
Show all
503 aa
57.7 kDa
No 1
CYP3A43-003
ENSP00000416581
ENST00000417625
Q9HB55 [Direct mapping]
Cytochrome P450 3A43
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
Show all
393 aa
44.8 kDa
No 2
CYP3A43-005
ENSP00000405557
ENST00000444905
C9JA26 [Direct mapping]
Cytochrome P450 3A43
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
167 aa
19.1 kDa
No 0
CYP3A43-006
ENSP00000401521
ENST00000415413
E9PDL8 [Direct mapping]
Cytochrome P450 3A43
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
292 aa
33.3 kDa
No 2
CYP3A43-013
ENSP00000312110
ENST00000312017
Q9HB55 [Direct mapping]
Cytochrome P450 3A43
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
Show all
420 aa
48.3 kDa
No 1
CYP3A43-014
ENSP00000222382
ENST00000222382
Q9HB55 [Direct mapping]
Cytochrome P450 3A43
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
Show all
504 aa
57.8 kDa
No 1
CYP3A43-201
ENSP00000345351
ENST00000342499
F8W6L8 [Direct mapping]
Cytochrome P450 3A43
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
126 aa
14.6 kDa
No 2
CYP3A43-202
ENSP00000486759
ENST00000631161
Q9HB50 [Direct mapping]
Cytochrome P450 3A43; Cytochrome P450 subfamily IIIA polypeptide 43
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
74 aa
8.6 kDa
No 1

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.