Fields »
ABOUT
HELP
BLOG
SPAST

CANCER ATLAS

Gene description

 Spastin

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017311

GENE INFORMATION

Gene name

 SPAST (HGNC Symbol)

Synonyms

 ADPSP, FSP2, KIAA1083, SPG4

Description

 Spastin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 32063611 - 32157637

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000021574 (version 83.38)

Entrez gene

 6683

UniProt

 Q9UBP0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBP0

Antibodypedia

 SPAST antibodies

PROTEIN BROWSER
SPAST-001
SPAST-002
SPAST-003
SPAST-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPAST-001
ENSP00000320885
ENST00000315285
Q9UBP0 [Direct mapping]
Spastin
E5KRP5 [Target identity:100%; Query identity:100%]
Spastin
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007409 [axonogenesis]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030496 [midbody]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031410 [cytoplasmic vesicle]
GO:0032467 [positive regulation of cytokinesis]
GO:0032506 [cytokinetic process]
GO:0034214 [protein hexamerization]
GO:0043014 [alpha-tubulin binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051013 [microtubule severing]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
Show all
 616 aa
67.2 kDa 		No 1
SPAST-002
ENSP00000340817
ENST00000345662
Q9UBP0 [Direct mapping]
Spastin
E5KRP6 [Target identity:100%; Query identity:100%]
Spastin
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007409 [axonogenesis]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030496 [midbody]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031410 [cytoplasmic vesicle]
GO:0032467 [positive regulation of cytokinesis]
GO:0032506 [cytokinetic process]
GO:0034214 [protein hexamerization]
GO:0043014 [alpha-tubulin binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051013 [microtubule severing]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
Show all
 584 aa
63.6 kDa 		No 1
SPAST-003
ENSP00000482496
ENST00000621856
Q9UBP0 [Direct mapping]
Spastin
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007409 [axonogenesis]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030496 [midbody]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031410 [cytoplasmic vesicle]
GO:0032467 [positive regulation of cytokinesis]
GO:0032506 [cytokinetic process]
GO:0034214 [protein hexamerization]
GO:0043014 [alpha-tubulin binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051013 [microtubule severing]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
Show all
 530 aa
58 kDa 		No 0
SPAST-201
ENSP00000480893
ENST00000615843
Q9UBP0 [Direct mapping]
Spastin
E5KRP5 [Target identity:100%; Query identity:100%]
Spastin
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007409 [axonogenesis]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0030496 [midbody]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031410 [cytoplasmic vesicle]
GO:0032467 [positive regulation of cytokinesis]
GO:0032506 [cytokinetic process]
GO:0034214 [protein hexamerization]
GO:0043014 [alpha-tubulin binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051013 [microtubule severing]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
Show all
 616 aa
67.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.