Cell atlas - OSBPL5 - The Human Protein Atlas

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OSBPL5

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	OSBPL5
Gene description	Oxysterol binding protein-like 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (NB-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA038335 , HPA038712
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038335	BJ	Vesicles
	HPA038335	HeLa	Vesicles
	HPA038335	U-2 OS	Vesicles
	HPA038712	BJ	Vesicles
	HPA038712	U-2 OS	Vesicles

GENE INFORMATION
Gene name	OSBPL5 (HGNC Symbol)
Synonyms	KIAA1534, ORP5
Description	Oxysterol binding protein-like 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	3087116 - 3166739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000021762 (version 83.38)
Entrez gene	114879
UniProt	Q9H0X9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0X9
Antibodypedia	OSBPL5 antibodies

PROTEIN BROWSER

OSBPL5-001	OSBPL5-002	OSBPL5-004	OSBPL5-010	OSBPL5-011	OSBPL5-012	OSBPL5-014	OSBPL5-015	OSBPL5-016	OSBPL5-017	OSBPL5-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL5-001 ENSP00000263650 ENST00000263650	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	879 aa 98.6 kDa	No	1
OSBPL5-002 ENSP00000374639 ENST00000389989	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	811 aa 90.8 kDa	No	1
OSBPL5-004 ENSP00000437141 ENST00000478260	E9PNH0 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		333 aa 37.8 kDa	No	1
OSBPL5-010 ENSP00000435812 ENST00000530372	E9PIJ6 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.8 kDa	No	0
OSBPL5-011 ENSP00000432507 ENST00000533721	E9PQB4 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.9 kDa	No	0
OSBPL5-012 ENSP00000433222 ENST00000534157	E9PLN3 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.6 kDa	No	0
OSBPL5-014 ENSP00000436950 ENST00000533234	E9PPQ2 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.5 kDa	No	0
OSBPL5-015 ENSP00000302872 ENST00000348039	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	811 aa 90.8 kDa	No	1
OSBPL5-016 ENSP00000433342 ENST00000525498	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	790 aa 88.4 kDa	No	1
OSBPL5-017 ENSP00000431412 ENST00000534454	H0YCD7 [Direct mapping] Oxysterol-binding protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006869 [lipid transport] Show all	432 aa 48.9 kDa	No	1
OSBPL5-018 ENSP00000433754 ENST00000526122	E9PJE6 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.