Cell atlas - C8B - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

C8B

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	C8B
Gene description	Complement component 8, beta polypeptide
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (Hep G2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	C8B
Synonyms
Description	Complement component 8, beta polypeptide (HGNC Symbol)
Entrez gene summary	This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	1
Cytoband	p32.2
Chromosome location (bp)	56929210 - 56966140
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000021852 (version 83.38)
Entrez gene	732
UniProt	P07358 (UniProt - Evidence at protein level)
neXtProt	NX_P07358
Antibodypedia	C8B antibodies

PROTEIN BROWSER

C8B-001	C8B-201	C8B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C8B-001 ENSP00000360281 ENST00000371237	P07358 [Direct mapping] Complement component C8 beta chain Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0016020 [membrane] GO:0019835 [cytolysis] GO:0030449 [regulation of complement activation] GO:0032403 [protein complex binding] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	591 aa 66.9 kDa	Yes	0
C8B-201 ENSP00000440113 ENST00000535057	F5GY80 [Direct mapping] Complement component C8 beta chain Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005579 [membrane attack complex] GO:0006955 [immune response] Show all	529 aa 60 kDa	No	0
C8B-202 ENSP00000442548 ENST00000543257	F5H7G1 [Direct mapping] Complement component C8 beta chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005579 [membrane attack complex] GO:0006955 [immune response] Show all	539 aa 61.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.