Fields »
ABOUT
HELP
BLOG
RB1CC1

CANCER ATLAS

Gene description

 RB1-inducible coiled-coil 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024391
HPA053049

GENE INFORMATION

Gene name

 RB1CC1 (HGNC Symbol)

Synonyms

 ATG17, Cc1, DRAGOU14, FIP200, KIAA0203, PPP1R131

Description

 RB1-inducible coiled-coil 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Chromosome

 8

Cytoband

 q11.23

Chromosome location (bp)

 52622456 - 52745843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023287 (version 83.38)

Entrez gene

 9821

UniProt

 Q8TDY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDY2

Antibodypedia

 RB1CC1 antibodies

PROTEIN BROWSER
RB1CC1-001
RB1CC1-002
RB1CC1-003
RB1CC1-004
RB1CC1-006
RB1CC1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RB1CC1-001
ENSP00000025008
ENST00000025008
Q8TDY2 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007254 [JNK cascade]
GO:0007507 [heart development]
GO:0010506 [regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0043066 [negative regulation of apoptotic process]
GO:0045793 [positive regulation of cell size]
GO:1990316 [ATG1/UKL1 kinase complex]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 1594 aa
183.1 kDa 		No 0
RB1CC1-002
ENSP00000396067
ENST00000435644
Q8TDY2 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0010506 [regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0034045 [pre-autophagosomal structure membrane]
GO:1990316 [ATG1/UKL1 kinase complex]
Show all
 1591 aa
182.8 kDa 		No 0
RB1CC1-003
ENSP00000429879
ENST00000518710
E5RH63 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034045 [pre-autophagosomal structure membrane]
Show all
 53 aa
6 kDa 		No 0
RB1CC1-004
ENSP00000429918
ENST00000517963
E5RH44 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034045 [pre-autophagosomal structure membrane]
Show all
 72 aa
7.3 kDa 		No 0
RB1CC1-006
ENSP00000429611
ENST00000518468
E5RHX0 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034045 [pre-autophagosomal structure membrane]
Show all
 15 aa
1.7 kDa 		No 0
RB1CC1-011
ENSP00000430809
ENST00000519912
H0YC30 [Direct mapping]
RB1-inducible coiled-coil protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034045 [pre-autophagosomal structure membrane]
Show all
 127 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.