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RNA tissue category: Group enriched (liver, small intestine, duodenum, gallbladder, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, kidney, colon, gallbladder)
GENE INFORMATION
Gene name
ABCC2 (HGNC Symbol)
Synonyms
CMOAT, cMRP, DJS, MRP2
Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]