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Most cancer tissues displayed weak to moderate nuclear immunoreactivity. Additional cytoplasmic staining was observed in a few prostate and urothelial cancers. Hepatocellular carcinomas and few prostate cancers displayed strong cytoplasmic immunoreactivity. Several lymphomas were negative.
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]