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Gene name

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Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

Score

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Antibodies

Column

 
 
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FAS
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FAS

Gene description

Fas cell surface death receptor

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA027444
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

FAS (HGNC Symbol)

Synonyms

APO-1, APT1, CD95, FAS1, TNFRSF6

Description

Fas cell surface death receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Chromosome

10

Cytoband

q23.31

Chromosome location (bp)

88990531 - 89015785

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000026103 (version 83.38)

Entrez gene

355

UniProt

P25445 (UniProt - Evidence at protein level)

neXtProt

NX_P25445

Antibodypedia

FAS antibodies

PROTEIN BROWSER

FAS-005
FAS-006
FAS-011
FAS-016
FAS-201
FAS-202
FAS-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FAS-005
ENSP00000347979
ENST00000355740
P25445 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001552 [ovarian follicle atresia]
GO:0001666 [response to hypoxia]
GO:0002020 [protease binding]
GO:0002377 [immunoglobulin production]
GO:0003014 [renal system process]
GO:0004871 [signal transducer activity]
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006925 [inflammatory cell apoptotic process]
GO:0006927 [transformed cell apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0007568 [aging]
GO:0007623 [circadian rhythm]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009636 [response to toxic substance]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010035 [response to inorganic substance]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010939 [regulation of necrotic cell death]
GO:0010942 [positive regulation of cell death]
GO:0012501 [programmed cell death]
GO:0016324 [apical plasma membrane]
GO:0019724 [B cell mediated immunity]
GO:0019900 [kinase binding]
GO:0021537 [telencephalon development]
GO:0030141 [secretory granule]
GO:0031104 [dendrite regeneration]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0032403 [protein complex binding]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0042127 [regulation of cell proliferation]
GO:0042383 [sarcolemma]
GO:0042493 [response to drug]
GO:0042698 [ovulation cycle]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043009 [chordate embryonic development]
GO:0043025 [neuronal cell body]
GO:0043029 [T cell homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043434 [response to peptide hormone]
GO:0043627 [response to estrogen]
GO:0045060 [negative thymic T cell selection]
GO:0045121 [membrane raft]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045637 [regulation of myeloid cell differentiation]
GO:0046898 [response to cycloheximide]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048536 [spleen development]
GO:0050869 [negative regulation of B cell activation]
GO:0051260 [protein homooligomerization]
GO:0051384 [response to glucocorticoid]
GO:0051402 [neuron apoptotic process]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070848 [response to growth factor]
GO:0071234 [cellular response to phenylalanine]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071279 [cellular response to cobalt ion]
GO:0071285 [cellular response to lithium ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071391 [cellular response to estrogen stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071455 [cellular response to hyperoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071464 [cellular response to hydrostatic pressure]
GO:0097049 [motor neuron apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097284 [hepatocyte apoptotic process]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097421 [liver regeneration]
GO:0097440 [apical dendrite]
GO:0097527 [necroptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902617 [response to fluoride]
GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
335 aa
37.7 kDa
Yes 1
FAS-006
ENSP00000349896
ENST00000357339
P25445 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007420 [brain development]
GO:0009986 [cell surface]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0019900 [kinase binding]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097527 [necroptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
314 aa
35.4 kDa
Yes 0
FAS-011
ENSP00000347426
ENST00000355279
P25445 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007420 [brain development]
GO:0009986 [cell surface]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0019900 [kinase binding]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097527 [necroptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
220 aa
24.8 kDa
Yes 1
FAS-016
ENSP00000345601
ENST00000352159
H7C5Z8 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
Show all
233 aa
26.4 kDa
Yes 1
FAS-201
ENSP00000477997
ENST00000612663
A0A087WTM9 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
Show all
216 aa
24.4 kDa
Yes 1
FAS-202
ENSP00000484575
ENST00000615406
A0A087X1Z7 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
Show all
254 aa
28.5 kDa
Yes 1
FAS-203
ENSP00000485876
ENST00000626542
A0A0D9SEP1 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
Show all
244 aa
27.6 kDa
Yes 1

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