Expression of KCNG1 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated modifier subfamily G, member 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA039530	HPA040024

GENE INFORMATION
Gene name	KCNG1 (HGNC Symbol)
Synonyms	K13, KCNG, kH2, Kv6.1
Description	Potassium channel, voltage gated modifier subfamily G, member 1 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	51003656 - 51023129
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000026559 (version 83.38)
Entrez gene	3755
UniProt	Q9UIX4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIX4
Antibodypedia	KCNG1 antibodies

PROTEIN BROWSER

KCNG1-001	KCNG1-002	KCNG1-003	KCNG1-004	KCNG1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNG1-001 ENSP00000394093 ENST00000424171	A2A2I8 [Direct mapping] Potassium voltage-gated channel subfamily G member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0051260 [protein homooligomerization] GO:0071805 [potassium ion transmembrane transport] Show all	180 aa 20.9 kDa	No	0
KCNG1-002 ENSP00000360626 ENST00000371571	Q9UIX4 [Direct mapping] Potassium voltage-gated channel subfamily G member 1 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:1902259 [regulation of delayed rectifier potassium channel activity] Show all	513 aa 57.9 kDa	No	7
KCNG1-003 ENSP00000408116 ENST00000433903	Q5JXL4 [Direct mapping] Potassium voltage-gated channel subfamily G member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0051260 [protein homooligomerization] GO:0071805 [potassium ion transmembrane transport] Show all	96 aa 11 kDa	No	0
KCNG1-004 ENSP00000394075 ENST00000439216	A0A075B6P6 [Direct mapping] Potassium voltage-gated channel subfamily G member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0071805 [potassium ion transmembrane transport] Show all	258 aa 29.5 kDa	No	1
KCNG1-005 ENSP00000396058 ENST00000447736	A2A2I9 [Direct mapping] Potassium voltage-gated channel subfamily G member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0071805 [potassium ion transmembrane transport] Show all	48 aa 5.4 kDa	No	0