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Cancer tissues of female genitalia, colorectal and breast cancers as well as several cases of skin and prostate cancers showed moderate to strong immunoreactivity. Remaining cancer tissues were weakly stained or negative.
Most cancer tissues displayed weak to moderate cytoplasmic positivity with additional nuclear staining in a few cases. Renal cancers showed moderate to strong staining.
Cancer tissues showed moderate often granular cytoplasmic staining. Papillary thyroid adenocarcinomas and a few cases of melanomas, renal and liver cancers were strongly stained.
The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]
