Expression of IFNGR1 in cancer - Summary

CANCER ATLAS

Gene description

Interferon gamma receptor 1

Protein class

CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA063871

GENE INFORMATION
Gene name	IFNGR1 (HGNC Symbol)
Synonyms	CD119, IFNGR
Description	Interferon gamma receptor 1 (HGNC Symbol)
Entrez gene summary	This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q23.3
Chromosome location (bp)	137197484 - 137219449
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000027697 (version 83.38)
Entrez gene	3459
UniProt	P15260 (UniProt - Evidence at protein level)
neXtProt	NX_P15260
Antibodypedia	IFNGR1 antibodies

PROTEIN BROWSER

IFNGR1-001	IFNGR1-002	IFNGR1-003	IFNGR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNGR1-001 ENSP00000356713 ENST00000367739	P15260 [Direct mapping] Interferon gamma receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004906 [interferon-gamma receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0009615 [response to virus] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019955 [cytokine binding] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] Show all	489 aa 54.4 kDa	Yes	1
IFNGR1-002 ENSP00000389249 ENST00000458076	Q5TFC9 [Direct mapping] Interferon gamma receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019955 [cytokine binding] Show all	210 aa 23.7 kDa	Yes	0
IFNGR1-003 ENSP00000394230 ENST00000414770	Q5TFD1 [Direct mapping] Interferon gamma receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019955 [cytokine binding] Show all	161 aa 18.6 kDa	No	0
IFNGR1-201 ENSP00000443282 ENST00000543628	F5H5M7 [Direct mapping] Interferon gamma receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019955 [cytokine binding] Show all	274 aa 31 kDa	Yes	1