We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in few cases. Carcinoids, skin and cervix cancers were negative.
Nuclear staining of varying intensity was observed in most malignant lymphomas. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
POU2F2 (HGNC Symbol)
Synonyms
OCT2, OTF2
Description
POU class 2 homeobox 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
P09086 [Direct mapping] POU domain, class 2, transcription factor 2
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P09086 [Direct mapping] POU domain, class 2, transcription factor 2
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P09086 [Direct mapping] POU domain, class 2, transcription factor 2
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P09086 [Direct mapping] POU domain, class 2, transcription factor 2
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002335 [mature B cell differentiation] GO:0002380 [immunoglobulin secretion involved in immune response] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] GO:0019904 [protein domain specific binding] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048305 [immunoglobulin secretion] GO:0048469 [cell maturation]
