Cell atlas - IBSP - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

IBSP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	IBSP
Gene description	Integrin-binding sialoprotein
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (U-138 MG)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	IBSP (HGNC Symbol)
Synonyms	BSP, BSP-II, SP-II
Description	Integrin-binding sialoprotein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	87799581 - 87812435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000029559 (version 83.38)
Entrez gene	3381
UniProt	P21815 (UniProt - Evidence at protein level)
neXtProt	NX_P21815
Antibodypedia	IBSP antibodies

PROTEIN BROWSER

IBSP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IBSP-001 ENSP00000226284 ENST00000226284	P21815 [Direct mapping] Bone sialoprotein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0001503 [ossification] GO:0001649 [osteoblast differentiation] GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0030282 [bone mineralization] GO:0031012 [extracellular matrix] GO:0031988 [membrane-bounded vesicle] GO:0071363 [cellular response to growth factor stimulus] Show all	317 aa 35.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.