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Malignant cells generally displayed moderate to strong cytoplasmic staining. Most malignant gliomas, breast, prostate, renal and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
BAK1 (HGNC Symbol)
Synonyms
BAK, BCL2L7, CDN1
Description
BCL2-antagonist/killer 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]