Cell atlas - IKZF2 - The Human Protein Atlas

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IKZF2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IKZF2
Gene description	IKAROS family zinc finger 2 (Helios)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (MOLT-4, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear bodies (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059142
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved), Nuclear bodies (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059142	HeLa	Nuclear bodies
	HPA059142	RT4	Nucleoplasm
	HPA059142	U-2 OS	Nucleoplasm
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	IKZF2 (HGNC Symbol)
Synonyms	Helios, ZNFN1A2
Description	IKAROS family zinc finger 2 (Helios) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	212999691 - 213152427
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000030419 (version 83.38)
Entrez gene	22807
UniProt	Q9UKS7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKS7
Antibodypedia	IKZF2 antibodies

PROTEIN BROWSER

IKZF2-001	IKZF2-002	IKZF2-003	IKZF2-004	IKZF2-013	IKZF2-014	IKZF2-201	IKZF2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IKZF2-001 ENSP00000412869 ENST00000434687	Q9UKS7 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0008150 [biological_process] GO:0042803 [protein homodimerization activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	526 aa 59.6 kDa	No	0
IKZF2-002 ENSP00000342876 ENST00000342002	B4DWF2 [Direct mapping] Zinc finger protein Helios; Zinc finger protein, subfamily 1A, 2 (Helios), isoform CRA_d; cDNA FLJ55795, highly similar to Zinc finger protein Helios Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	532 aa 60.3 kDa	No	0
IKZF2-003 ENSP00000363439 ENST00000374319	Q9UKS7 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0008150 [biological_process] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	500 aa 56.8 kDa	No	0
IKZF2-004 ENSP00000390045 ENST00000442445	E7ES26 [Direct mapping] Zinc finger protein Helios Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.4 kDa	No	0
IKZF2-013 ENSP00000402132 ENST00000452786	E7EPU0 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		83 aa 9.2 kDa	No	0
IKZF2-014 ENSP00000406783 ENST00000433134	E7EUI1 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14 kDa	No	0
IKZF2-201 ENSP00000395203 ENST00000451136	A0A0A0MSL2 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	409 aa 46.7 kDa	No	0
IKZF2-202 ENSP00000410447 ENST00000457361	A0A0A0MT14 [Direct mapping] Zinc finger protein Helios Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	411 aa 46.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.