Cell atlas - ZCCHC8 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ZCCHC8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ZCCHC8
Gene description	Zinc finger, CCHC domain containing 8
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA037483 , HPA037484
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (validated)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037483	A-431	Nucleoplasm
HPA037483	U-2 OS	Nucleus
HPA037483	U-251 MG	Nucleoplasm
HPA037484	A-431	Nucleoplasm
HPA037484	U-2 OS	Nucleoplasm
HPA037484	U-2 OS	Nuclear bodies
HPA037484	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	ZCCHC8 (HGNC Symbol)
Synonyms	DKFZp434E2220
Description	Zinc finger, CCHC domain containing 8 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122471600 - 122501073
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000033030 (version 83.38)
Entrez gene	55596
UniProt	Q6NZY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NZY4
Antibodypedia	ZCCHC8 antibodies

PROTEIN BROWSER

ZCCHC8-001	ZCCHC8-002	ZCCHC8-003	ZCCHC8-004	ZCCHC8-006	ZCCHC8-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZCCHC8-001 ENSP00000488055 ENST00000633063	Q6NZY4 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	707 aa 78.6 kDa	No	0
ZCCHC8-002 ENSP00000438993 ENST00000543897	Q6NZY4 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	469 aa 51.1 kDa	No	0
ZCCHC8-003 ENSP00000441423 ENST00000536306	Q6NZY4 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	469 aa 51.1 kDa	No	0
ZCCHC8-004 ENSP00000440234 ENST00000540586	F5GYI9 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.5 kDa	No	0
ZCCHC8-006 ENSP00000437578 ENST00000536663	F5H6J5 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	185 aa 20.9 kDa	No	0
ZCCHC8-007 ENSP00000441112 ENST00000544054	F5GX80 [Direct mapping] Zinc finger CCHC domain-containing protein 8 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	211 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.