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Most cancer tissues showed moderate to strong cytoplasmic positivity with a granular pattern. Several lymphomas, skin, cervical cancers and a few gliomas, renal cell carcinomas and hepatocellular carcinomas were weakly stained.
Most cancer tissues displayed weak to moderate cytoplasmic staining. Strong positivity was observed in a few seminomas, breast, gastrointestinal and pancreatic cancers. Gliomas and skin cancers were weakly stained or negative.
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)